ISBN: 3-540-65127-6
TITLE: Osteoarthritis
AUTHOR: Reginster, J.-Y.; Pelletier, J.-P.; Martel-Pelletier, J.; Henrotin, Y. (Eds.)
TOC:

1 Structure and Function of Normal Human Adult Articular Cartilage 1 
E.J-M.A. Thonar, K. Masuda, D.H Manicourt, 
and K.E. Kuettner 
2 Epidemiology and Economic Consequences of Osteoarthritis 20 
2.1 The American Viewpoint 20 
J.C. Scott, M. Lethbridge-Cejku, and M.C. Hochberg 
2.2 The European Viewpoint 38 
X. Badia Llach 
3 Experimental Models of Osteoarthritis 53 
3.1 In Vitro Models for the Study of Cartilage Damage and Repair 53 
Y. Henrotin and J.-Y. Reginster 
3.2 Animal Models of Osteoarthritis 81 
K.D. Brandt 
4 Pathophysiology of Osteoarthritis 101 
4.1 Role of Mechanical Factors in the Aetiology, Pathogenesis 
and Progression of Osteoarthritis 101 
G. Nuki 
4.2 Role of Biomechanical Factors 115 
P. Ghosh 
4.3 Genetic and Metabolic Aspects 134 
C.J. Williams and S.A. Jimenez 
4.4 Biochemical Factors in Joint Articular Tissue Degradation 
in Osteoarthritis 156 
J. Martel-Pelletier, J. Di Battista, and D. Lajeunesse 
4.5 Role of Growth Factors and Cartilage Repair 188 
W.B. van den Berg, P.M. van der Kraan, 
and H.M. van Beuningen 
4.6 Role of Crystal Deposition in the Osteoarthritic Joint 210 
G.M. McCarthy 
5 Diagnosis and Monitoring of Osteoarthritis 228 
5.1 Direct Visualization of the Cartilage 228 
X. Ayral and M. Dougados 
5.2 Radiographic Imaging of Osteoarthritis 246 
C. Buckland-Wright 
5.3 Magnetic Resonance Imaging in Osteoarthritis 268 
Y. Jiang, C.G. Peterfy, J.J. Zhao, D.L. White, J.A. Lynch, 
and H.K. Genant 
5.4 The Role of Molecular Markers to Monitor Breakdown and Repair 296 
L.S. Lohmander 
6 Evolution and Prognosis of Osteoarthritis 312 
E. Veys and G. Verbruggen 
7 Impact of Osteoarthritis on Quality of Life 331 
J. Pouchot, J. Coste, and F. Guillemin 
8 Medical Management of Osteoarthritis 356 
8.1 Medical Aspects 356 
8.1.1 Basic Principles in Osteoarthritis Treatment 356 
D. Choquette, J.-P. Raynauld, and E. Rich 
8.1.2 Non-steroidal Anti-inflammatory Drug Administration 
in the Treatment of Osteoarthritis 370 
J.T. Dingle 
8.1.3 New and Future Therapies for Osteoarthritis 387 
J.-P. Pelletier, B. Haraoui, and J.C. Fernandes 
8.2 Regulatory Requirements 408 
8.2.1 Preclinical Studies in Osteoarthritis 408 
M. Sisay and R.D. Altman 
8.2.2 Clinical Evaluation of Drug Therapy 421 
J.-Y. Reginster, B. Avouac, and C. Gosset 
9 Surgical Treatment of the Cartilage Injuries 431 
M. Brittberg 
10 Scientific Basis of Physical Therapy and Rehabilitation 
in the Management of Patients with Osteoarthritis 453 
J-M. Crielaard and Y. Henrotin 
11 Conclusion and Perspectives 480 
M. Lequesne and L. Punzi 
Subject Index 511 
END
