ISBN: 3-540-66830-6
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Sepsis and Inflammation
The Molecular Genetics of Sepsis: Clinical Epidemiology Considerations 3
(RS Wax and DC Angus)
The Role of Interleukin (IL)-12 and IL-18 During Endotoxemia and Bacterial Infection 18
(FN Lauw, SJH van Deventer, and T van der Poll)
The Apoptotic Response of the Lymphoid Immune System to Trauma, Shock, and Sepsis 27
(C-S Chung, IH Chaudry, and A Ayala)
Modulation of Neutrophil Function in Sepsis 41
(W Karzai and K Reinhart)
Trauma-Induced Immunosuppression: Pathogenesis and Treatment 51
(ER Sherwood and A Koutrouvelis)
The Influence of Nutrition on Mucosal Immunology and Endothelial Cell Adhesion Molecules 63
(BL Zarzaur, K Fukatsu, and KA Kudsk)
Intestinal Microcirculation: Changes in Sepsis and Effect of Vasoactive Manipulation 72
(LCH Tham, CM Martin, and WJ Sibbald)
Microvascular Permeability in Experimental Sepsis: Mechanisms, Modulation and Management 80
(S Singh, CP Winlove, and TW Evans)
Infectious Challenges
Catheter-Related Infections in the ICU 95
(P Eggimann and D Pittet )
Ecological Impact of Beta-lactam Treatment on Normal Human Intestinal Microflora 111
(C Edlund, M Hedberg, and CE Nord)
Non-Pharmacologic Prevention of Ventilator-Associated Pneumonia (VAP) 123
(MH Kollef)
Fungal Infections
Fungal Infections in Critically Ill Surgical Patients 135
(PA Lipsett)
Candida: Some Thoughts 144
(N Soni)
Steroid Therapy
Clinical Impact of Glucocorticoid Pharmacodynamics 163
(T Hirano, K Oka, and T Nagao)
Corticosteroids in the Acute Respiratory Distress Syndrome 169
(M Antonelli, G Conti, and R Proietti )
Corticosteroid Therapy in Critical Illness: A Changing Paradigm 175
(N Ahmed and JC Marshall)
Pathophysiology of Lung Injury
Alveolar Epithelial Barrier: Acute Lung Injury 189
(MA Matthay, T Nuckton, and B Daniel)
Pulmonary Oxygen Toxicity in Man: Emerging Concepts in Pathogenesis and Prevention 206
(NS Ward and MM Levy)
Fibrosis in ARDS: How Close is the Link between Inflammation and Fibroproliferation? 217
(GJ Bellingan, RJ Marshall, and GJ Laurent)
The Clinical Relevance of Exhaled Nitric Oxide: A Critical Review 225
(H Gerlach)
Acute Respiratory Failure
Hypoxemia and Mortality in the ICU 239
(JD Young)
Diffuse Alveolar Hemorrhage in the ICU 247
(TS van der Werf)
Optimal Positioning for the Adult Intensive Care Patient while Prone 256
(M Barker and R Beale)
Mechanical Ventilation
Utilization of Mechanical Ventilation in Critical Care 265
(A Anzueto and A Esteban)
Respiratory Physiology as a Basis for the Management of Acute Lung Injury 283
(S Grasso, F Giunta, and VM Ranieri)
High Frequency Oscillatory Ventilation: A Tool to Decrease Ventilator-Induced Lung Injury? 290
(ND Ferguson, TE Stewart, and AS Slutsky)
Extubation Failure 305
(SK Epstein)
Non-invasive Ventilation: Why Does It Fail? 318
(MJ Moore and GA Schmidt)
Surgery
Reducing the Morbidity and Mortality of High-Risk Surgical Patients 331
(J Ball, A Rhodes, and ED Bennett)
Causes of Oxygenation Impairment During Anesthesia 343
(G Hedenstierna)
Respiratory Function in Obese Patients in the Peri-operative Period 352
(P Pelosi, N Bottino, and L Gattinoni)
Post-operative Myocardial Ischemia and Infarction 365
(P Fox)
Abdominal Crises
Novel Strategies for the Management of Severe Acute Pancreatitis 379
(R Andersson, G Eckerwall, and P Haraldsen)
The Hepatorenal Syndrome 390
(MG Phillips, R Harry, and J Wendon)
Sedation
Sedation in the Intensive Care Environment 405
(M Maze)
Intensive Care Sedation: The Alpha-2 Agonists 414
(RM Venn, A Steele, and RM Grounds)
Intravenous Fluids
Fluid Therapy: Present Controversies 429
(H Haljame and S Lindgren)
Crystalloids versus Colloids in the Treatment of Hypovolemic Shock 443
(JF Baron)
Human Albumin on the ICU: Can We Live Without It? 467
(J Boldt)
Intra-operative Use of Hypertonic Solutions 476
(S Tllfsrud and GC Kramer)
Adverse Effects of Colloids on Renal Function 486
(JF Baron)
Should Old Red Cells be Transfused in Critically Ill Patients? 494
(PC Hbert and I Chin-Yee)
Current Status of Artificial Oxygen Carriers 507
(DR Spahn)
Emergencies
Intensive Care in a Forward Deployed Military Field Surgical Combat Support Hospital 521
(SM Grosso, CW Scott, and JO Keenan)
Diagnosis of Traumatic Aortic Injuries 534
(P Vignon)
Diagnosis and Treatment of Hyperosmolar Emergencies 544
(JA Kruse)
Neurology
Conservative and Invasive Treatment of Space-Occupying Hemispheric Stroke 563
(T Steiner, P Ringleb, and W Hacke)
Thrombolytic Therapy for Intraventricular and Intraparenchymal Hemorrhage 577
(JR Carhuapoma, NJ Naff, and DF Hanley)
Cerebral Function in Vegetative State studied by Positron Emission Tomography 587
(S Laureys, ME Faymonville, and M Lamy)
Cardiovascular Crises
Evaluation of Platelet Membrane Glycoproteins in Ischemic Heart Disease 601
(S Massberg, I Mller, and M Gawaz)
Coronary Thrombosis and Myocardial Infarction 620
(C de Zwaan, AJM Oude Ophuis, and FWA Br)
Diagnosis and Treatment of Tachycardias 638
(H-J Trappe)
Cardiopulmonary Resuscitation: Lessons from the Past and Trends for the Future 649
(PE Marik and J Varon)
Effects of Catecholamine Therapy on Regional Perfusion in Septic Shock 658
(MM Treggiari-Venzi, PM Suter, and JA Romand)
ICU Monitoring
Evaluation of Cardiac Output and Cardiac Preload 671
(SG Sakka and A Meier-Hellmann)
Transesophageal Echocardiography: The Relationship between Pressure, Flow and Function 680
(JI Poelaert, G Schpfer, and G Poortmans)
Respiratory Changes in Arterial Pressure in Mechanically Ventilated Patients 696
(F Michard and J-L Teboul)
The Study of the Microcirculation using Orthogonal Polarization Spectral Imaging 705
(AG Harris, S Langer, and K Messmer)
Assessment of Tissue Oxygenation in the Critically Ill 715
(B Vallet, B Tavernier, and N Lund)
Blood Gas Monitoring with Optodes 726
(CK Mahutte and TS Gallacher)
Interpretation of Changes in Regional and Mucosal PCO2 Gradients: The Haldane Effect 736
(SM Jakob and J Takala)
The Meaning of Lactate 743
(S Subramanian and JA Kellum)
Routine Assessment of Tissue Metabolism in the Critically Ill 752
(RJ Cusack, PJ Newman, and A Rhodes)
ICU Costs
The Costs of Infection in the ICU 763
(H Burchardi, D Schrgers, and O Mrer)
Costs of Antibiotic Therapy: Maximizing Effectiveness While Minimizing Cost 770
(M-K Kim and CH Nightingale)
Clinical Pathways as a Tool for "Intelligent" Rationing in Intensive Care 781
(M Imhoff)
2000 and Beyond
The Constraints and Necessity of Teaching Emergency Medicine to Medical Students 795
(B Vermeulen, NV Vu, and PF Unger)
ICU Organization: Does it Matter? 809
(MP Young, SD Surgenor, and HL Corwin)
Training of Young Intensivists in Management Skills for the New Millennium 816
(V Kvetan)
Outcome Prediction in Intensive Care 825
(R Moreno)
Critical Care in the Elderly: The Final Challenge 837
(S Ridley)
Subject Index 849
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