Chapter 17/Figure 2.JPG
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Standard
histological stains verify potential lesion sites identified in MRM scanned
rat brain hemisphere. A rat brain from an animal 48 hr post domoic acid
injection is scanned using MRM. A slice with potential lesions is identified.
This is compared to a section from a control rat in a similar region of
the brain. Sections are cut from the scanned brain around the identified
site and then stained using conventional histological stains. These stains
verify that there is significant neuronal loss in the amygdala, typical
for domoic acid treatment. A total of 7 stains were required to identify
all of the potential lesion sites observed in the MRM scans. In this figure,
two lesions are identifiable, in the cortex and the cortical cell layer
of the amygdalla. The stains necessary to identify these pathologies are
included. |
