## Chapter 17/Figure 6.JPG Back | Home | Next | Comparison of conventional histological staining to MRM imaging for the detection of 6-hydroxy dopamine induced neurotoxicity in rat brain. A section has been selected which demonstrates the damage caused by the treatment with the toxin. Sections were cut from this region of the brain. The conventional Nissl stained section from this region does not show significant differences at this level of magnification (A). A second section from this region has been stained with tyrosine hydroxylase, an established marker for dopaminergic neurons. As can be seen, there is a significant depletion of staining in the substantia nigra in the treated hemisphere (B). The MRM section has been pseudocolored in order to visualize subtle contrast differences (C). The left and right hemispheres have diffuse regions of contrast differences indicating that the unilateral treatment has significant effects.